Immunoinformatics-aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019-nCoV.
Identifieur interne : 000566 ( 2020/Analysis ); précédent : 000565; suivant : 000567Immunoinformatics-aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019-nCoV.
Auteurs : Vargab Baruah [Inde] ; Sujoy Bose [Inde]Source :
- Journal of medical virology [ 1096-9071 ] ; 2020.
Descripteurs français
- KwdFr :
- Antigènes d'histocompatibilité de classe I (immunologie), Biologie informatique, Chine, Déterminants antigéniques des lymphocytes B (immunologie), Déterminants antigéniques des lymphocytes T (immunologie), Humains, Infections à coronavirus, Pneumopathie virale, Protéines de l'enveloppe virale (immunologie), Simulation de dynamique moléculaire, Structure tertiaire des protéines.
- MESH :
- immunologie : Antigènes d'histocompatibilité de classe I, Déterminants antigéniques des lymphocytes B, Déterminants antigéniques des lymphocytes T, Protéines de l'enveloppe virale.
- Biologie informatique, Chine, Humains, Infections à coronavirus, Pneumopathie virale, Simulation de dynamique moléculaire, Structure tertiaire des protéines.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Betacoronavirus (immunology), China, Computational Biology, Coronavirus Infections, Epitopes, B-Lymphocyte (immunology), Epitopes, T-Lymphocyte (immunology), Histocompatibility Antigens Class I (immunology), Humans, Molecular Dynamics Simulation, Pneumonia, Viral, Protein Structure, Tertiary, Viral Envelope Proteins (immunology).
- MESH :
- chemical , immunology : Epitopes, B-Lymphocyte, Epitopes, T-Lymphocyte, Histocompatibility Antigens Class I, Viral Envelope Proteins.
- geographic : China.
- immunology : Betacoronavirus.
- Computational Biology, Coronavirus Infections, Humans, Molecular Dynamics Simulation, Pneumonia, Viral, Protein Structure, Tertiary.
Abstract
The 2019 novel coronavirus (2019-nCoV) outbreak has caused a large number of deaths with thousands of confirmed cases worldwide, especially in East Asia. This study took an immunoinformatics approach to identify significant cytotoxic T lymphocyte (CTL) and B cell epitopes in the 2019-nCoV surface glycoprotein. Also, interactions between identified CTL epitopes and their corresponding major histocompatibility complex (MHC) class I supertype representatives prevalent in China were studied by molecular dynamics simulations. We identified five CTL epitopes, three sequential B cell epitopes and five discontinuous B cell epitopes in the viral surface glycoprotein. Also, during simulations, the CTL epitopes were observed to be binding MHC class I peptide-binding grooves via multiple contacts, with continuous hydrogen bonds and salt bridge anchors, indicating their potential in generating immune responses. Some of these identified epitopes can be potential candidates for the development of 2019-nCoV vaccines.
DOI: 10.1002/jmv.25698
PubMed: 32022276
Affiliations:
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pubmed:32022276Le document en format XML
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Gauhati University, Guwahati, Assam, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, Gauhati University, Guwahati, Assam</wicri:regionArea><wicri:noRegion>Assam</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of medical virology</title><idno type="eISSN">1096-9071</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (immunology)</term><term>China</term><term>Computational Biology</term><term>Coronavirus Infections</term><term>Epitopes, B-Lymphocyte (immunology)</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>Histocompatibility Antigens Class I (immunology)</term><term>Humans</term><term>Molecular Dynamics Simulation</term><term>Pneumonia, Viral</term><term>Protein Structure, Tertiary</term><term>Viral Envelope Proteins 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type="abstract" xml:lang="en">The 2019 novel coronavirus (2019-nCoV) outbreak has caused a large number of deaths with thousands of confirmed cases worldwide, especially in East Asia. This study took an immunoinformatics approach to identify significant cytotoxic T lymphocyte (CTL) and B cell epitopes in the 2019-nCoV surface glycoprotein. Also, interactions between identified CTL epitopes and their corresponding major histocompatibility complex (MHC) class I supertype representatives prevalent in China were studied by molecular dynamics simulations. We identified five CTL epitopes, three sequential B cell epitopes and five discontinuous B cell epitopes in the viral surface glycoprotein. Also, during simulations, the CTL epitopes were observed to be binding MHC class I peptide-binding grooves via multiple contacts, with continuous hydrogen bonds and salt bridge anchors, indicating their potential in generating immune responses. Some of these identified epitopes can be potential candidates for the development of 2019-nCoV vaccines.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Baruah, Vargab" sort="Baruah, Vargab" uniqKey="Baruah V" first="Vargab" last="Baruah">Vargab Baruah</name></noRegion><name sortKey="Bose, Sujoy" sort="Bose, Sujoy" uniqKey="Bose S" first="Sujoy" last="Bose">Sujoy Bose</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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